A biomimetic upconversion nanoreactors for near-infrared driven H₂ release to inhibit tauopathy in Alzheimer's disease therapy.

ABSTRACT: Abnormal hyperphosphorylation of tau protein is a principal pathological hallmark in the onset of neurodegenerative disorders, such as Alzheimer's disease (AD), which can be induced by an excess of reactive oxygen species (ROS). As an antioxidant, hydrogen gas (H₂) has the potential to mitigate AD by scavenging highly harmful ROS such as •OH. However, conventional administration methods of H₂ face significant challenges in controlling H₂ release on demand and fail to achieve effective accumulation at lesion sites. Herein, we report artificial nanoreactors that mimic natural photosynthesis to realize near-infrared (NIR) light-driven photocatalytic H₂ evolution in situ. The nanoreactors are constructed by biocompatible crosslinked vesicles (CVs) en

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11402069 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature