Association between baseline lipid profile and risk of worsening in patients with myasthenia gravis: A retrospective cohort study.

ABSTRACT:

Background

Dyslipidemia has been implicated in autoimmunity; however, its association with myasthenia gravis (MG) prognosis is unclear. We aimed to investigate the correlation between baseline lipid profiles and risk of MG worsening.

Methods

This 7-year retrospective cohort study conducted at a Chinese hospital included 264 adult patients with MG. Data on baseline lipids, 1-year worsening, and covariates, including demographics, MG characteristics, comorbidities, and treatments were extracted.

Results

Univariate and multivariate logistic regression analyses failed to show a significant association between the risk of 1-year MG worsening and any of the seven blood lipid-related indicators. However, the subsequent non-linear analysis revealed an inflection point in the

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11402134 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature