Gene interactions analysis of brain spatial transcriptome for Alzheimer's disease.

ABSTRACT: Recent studies have explored the spatial transcriptomics patterns of Alzheimer's disease (AD) brain by spatial sequencing in mouse models, enabling the identification of unique genome-wide transcriptomic features associated with different spatial regions and pathological status. However, the dynamics of gene interactions that occur during amyloid-β accumulation remain largely unknown. In this study, we performed analyses on ligand-receptor communication, transcription factor regulatory network, and spot-specific network to reveal the dependence and the dynamics of gene associations/interactions on spatial regions and pathological status with mouse and human brains. We first used a spatial transcriptomics dataset of the App ^NL-G-F knock-in AD and wild-type mouse mod

SUBMITTER: Wang S 

PROVIDER: S-EPMC11402150 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature