Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli.

ABSTRACT: The increase in bacterial antibiotic resistance poses a significant threat to the effectiveness of antibiotics, and there is growing evidence suggesting that global warming may speed up this process. However, the direct influence of temperature on the development of antibiotic resistance and the underlying mechanisms is not yet fully understood. Here we show that antibiotic resistance exhibits a nonlinear response to elevated temperatures under the combined stress of temperatures and antibiotics. We find that the effectiveness of gatifloxacin against Escherichia coli significantly diminishes at 42 °C, while resistance increases 256-fold at 27 °C. Additionally, the increased transcription levels of genes such as marA, ygfA, and ibpB with rising temperatures, alon

SUBMITTER: Zhao W 

PROVIDER: S-EPMC11402153 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature