The PerioGene North Study Uncovers Serum Proteins Related to Periodontitis.

ABSTRACT: The sequalae of periodontitis include irreversible degradation of tooth-supporting structures and circulatory spread of inflammatory mediators. However, the serum protein profile in periodontitis is not well described, which is partly attributable to the limited number of studies based on large and well-characterized periodontitis cohorts. This study aims to identify novel, circulating inflammation-related proteins associated with periodontitis within the PerioGene North case-control study, which includes 478 cases with severe periodontitis and 509 periodontally healthy controls. The serum concentrations of high-sensitivity C-reactive protein (hs-CRP) and a panel of 45 inflammation-related proteins were analyzed using targeted proteomics. A distinguishable serum protein profile was evident

SUBMITTER: Wanman M 

PROVIDER: S-EPMC11402264 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature