Neurophysiological markers of disease severity and cognitive dysfunction in major depressive disorder: A TMS-EEG study.

ABSTRACT:

Background

Transcranial magnetic stimulation-electroencephalography (TMS-EEG) is a powerful technique to study the neuropathology and biomarkers of major depressive disorder (MDD). This study investigated cortical activity and its relationship with clinical symptoms and cognitive dysfunction in MDD patients by indexing TMS-EEG biomarkers in the dorsolateral prefrontal cortex (DLPFC).

Methods

133 patients with MDD and 76 healthy individuals participated in this study. Single-pulse TMS was performed on the left DLPFC to obtain TMS-evoked potential (TEP) indices. TMS-EEG waveforms and components were determined by global mean field amplitude. We used the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to measure participants' cognitive function.

Re

SUBMITTER: Li D 

PROVIDER: S-EPMC11402404 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature