Mass chemotherapy with niclosamide for the control of Taenia solium: population-based safety profile and treatment effectiveness.

ABSTRACT:

Background

Mass drug administration (MDA) with niclosamide (NSM) can be used to control taeniasis, the cause of neurocysticercosis. NSM is 84.3% effective against taeniasis and is considered safe as it is not absorbed from the intestinal tract. However, information on its safety and effectiveness during MDA is limited. We evaluated the effectiveness of NSM and reported adverse events (AEs) during a cysticercosis elimination program in Tumbes, Peru.

Methods

Three rounds of NSM at 4-month intervals were offered to 77,397 eligible residents. We revisited all participants in their homes 72 h after each round to collect information regarding AEs. We also collected post-treatment stool samples to diagnose taeniasis after the first round, followed by a second sample at 30 days from

SUBMITTER: Wardle MT 

PROVIDER: S-EPMC11402444 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature