Magnetic stirring with iron oxide nanospinners accretes neurotoxic Aβ₄₂ oligomers into phagocytic clearable plaques for Alzheimer's disease treatment.

ABSTRACT: An increasing number of medications have been explored to treat the progressive and irreversible Alzheimer's disease (AD) that stands as the predominant form of dementia among neurodegenerative ailments. However, assertions about toxic side effects of these drugs are a significant hurdle to overcome, calling for drug-free nanotherapeutics. Herein, a new therapeutic strategy devoid of conventional drugs or other cytotoxic species was developed. The constructed superparamagnetic iron oxide nanoparticles (SPIONs) nanospinners can accrete neurotoxic β-amyloid 42 oligomers (oAβ₄₂) into aggregated magnetic plaques (mpAβ) by mechanical rotating force via remote interaction between nanoparticles and the applied magnetic field. While the cellular uptake of mpAβ attained from the magnetic

SUBMITTER: Sabu A 

PROVIDER: S-EPMC11402446 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature