Chronic nasal inflammation early in life induces transient and long-term dysbiosis of gut microbiota in mice.

ABSTRACT: The gut microbiota begins to colonize the host body following birth, develops during the suckling period and changes to the adult type after weaning. The early gut microbiota during the suckling period is thought to have profound effects on the host physiology throughout life but it is still unclear whether early dysbiosis is retained lifelong. Our previous study indicated that chronic nasal inflammation induces dysbiosis of gut microbiota in adult mice. In the present study, we addressed the question as to whether early exposure to chronic nasal inflammation induces dysbiosis, and if so, whether the dysbiosis is retained until adulthood and the sex differences in this effect. Male and female mice received repeated intranasal administration of lipopolysaccharide (LPS) or saline twice a wee

SUBMITTER: Hasegawa-Ishii S 

PROVIDER: S-EPMC11402449 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature