Obese mice have decreased uterine contractility and altered energy metabolism in the uterus at term gestation†.

ABSTRACT: Over 35% of reproductive-age women in the USA have obesity, putting them at increased risk for numerous obstetric complications due to abnormal labor. While the association between maternal obesity and abnormal labor has been well documented, the mechanisms responsible for this remain understudied. The uterine smooth muscle, myometrium, has high energy needs in order to fuel regular uterine contractions during parturition. However, the precise mechanisms by which the myometrium meets its energy demands has not been defined. Here, our objective was to define the effects of obesity on energy utilization in the myometrium during labor. We generated a mouse model of maternal diet-induced obesity and found that these mice had a higher rate of dystocia than control chow-fed mice. Moreover, compa

SUBMITTER: Prifti KK 

PROVIDER: S-EPMC11402524 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature