Effects of social dominance and acute social stress on morphology of microglia and structural integrity of the medial prefrontal cortex.

ABSTRACT: Chronic stress increases activity of the brain's innate immune system and impairs function of the medial prefrontal cortex (mPFC). However, whether acute stress triggers similar neuroimmune mechanisms is poorly understood. Across four studies, we used a Syrian hamster model to investigate whether acute stress drives changes in mPFC microglia in a time-, subregion-, and social status-dependent manner. We found that acute social defeat increased expression of ionized calcium binding adapter molecule 1 (Iba1) in the infralimbic (IL) and prelimbic (PL) and altered the morphology Iba1+ cells 1, 2, and 7 days after social defeat. We also investigated whether acute defeat induced tissue degeneration and reductions of synaptic plasticity 2 days post-defeat. We found that while social defeat increa

SUBMITTER: Grizzell JA 

PROVIDER: S-EPMC11402560 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature