Utilization of geospatial distribution in the measurement of study cohort representativeness.

ABSTRACT:

Objective

The ability to apply results from a study to a broader population remains a primary objective in translational science. Distinct from intrinsic elements of scientific rigor, the extrinsic concept of generalization requires there be alignment between a study cohort and population in which results are expected to be applied. Widespread efforts have been made to quantify representativeness of study cohorts. These techniques, however, often consider the study and target cohorts as monolithic collections that can be directly compared. Overlooking known impacts to health from socio-demographic and environmental factors tied to individual's geographical location, and potentially obfuscating misalignment in underrepresented population subgroups. This manuscript introduces several

SUBMITTER: Feldman K 

PROVIDER: S-EPMC11402570 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature