Clinicopathological and molecular differences between stage IV screen-detected and interval colorectal cancers in the Flemish screening program.

ABSTRACT:

Introduction

Interval cancer (IC) is an important quality indicator in colorectal cancer (CRC) screening. Previously, we found that fecal immunochemical test (FIT) ICs are more common in women, older age, right-sided tumors, and advanced stage. Here, we extended our existing stage IV patient cohort with clinicopathological and molecular characteristics, to identify factors associated with FIT-IC.

Methods

Logistic regression models were fit to identify variables associated with the odds of having a stage IV FIT-IC. Multivariate models were corrected for gender, age, and location.

Results

A total of 292 screen-detected (SD) CRCs and 215 FIT-IC CRCs were included. FIT-IC CRC had 5 fold higher odds to be a neuroendocrine (NET) tumor and 2.5 fold higher odds to have lympho

SUBMITTER: Neefs I 

PROVIDER: S-EPMC11402608 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature