Inhibition of ADAM17 increases the cytotoxic effect of cisplatin in cervical spheroids and organoids.

ABSTRACT:

Introduction

Cervical cancer represents one of the main causes of female, cancer-related mortality worldwide. The majority of cancers are caused by human papillomaviruses such as HPV16 and HPV18. As chemotherapeutic resistance to first-line platinum treatment is still a predominant clinical challenge in advanced cervical cancer, novel treatment options including combinatorial therapies are urgently required to overcome chemotherapeutic resistance. Inhibition of A Disintegrin And Metalloproteinase (ADAM)-family members, heavily involved in tumour progression of a vast range of solid tumours, strongly improved response to chemotherapeutic treatment in other tumour entities including ovarian cancer.

Methods

We established two- and three-dimensional models derived from three tra

SUBMITTER: Holthaus D 

PROVIDER: S-EPMC11402614 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature