Collagen extracellular matrix promotes gastric cancer immune evasion by activating IL4I1-AHR signaling.

ABSTRACT:

Background

Gastric cancer (GC) remains a significant global health challenge with poor prognosis, partly due to its ability to evade the immune system. The extracellular matrix (ECM), particularly collagen, plays a crucial role in tumor immune evasion, but the underlying mechanisms are not fully understood. This study investigates the role of collagen ECM in promoting immune evasion in gastric cancer by activating the IL4I1-AHR signaling pathway.

Methods

We cultured gastric cancer cells in 3D collagen gels and assessed their immune evasion capabilities by co-culturing with HER2-specific CAR-T cells. The expression of IL4I1 and its metabolites was analyzed, and the role of integrin αvβ1 in mediating the effects of collagen was explored. Additionally, the impact of IL4I1-induc

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11402615 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature