Exploring the top 30 drugs associated with drug-induced constipation based on the FDA adverse event reporting system.

ABSTRACT:

Objective

This project aims to identify the top 30 drugs most commonly associated with constipation and their signal values within the FDA Adverse Event Reporting System database.

Methods

We extracted adverse drug events (ADEs) related to constipation from the FAERS database spanning from January 1, 2004, to September 30, 2023. We compiled the 30 most frequently reported drugs based on the frequency of constipation events. We employed signal detection methodologies to ascertain whether these drugs elicited significant signals, including reporting odds ratio, proportional reporting ratio, multi-item gamma Poisson shrinker, and information component given by the Bayesian confidence propagation neural network. Furthermore, we conducted a time-to-onset (TTO) analysis for drugs g

SUBMITTER: Li W 

PROVIDER: S-EPMC11402663 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature