Effects of simulated space conditions on CD4+ T cells: a multi modal analysis.

ABSTRACT:

Introduction

The immune system is an intricate network of cellular components that safeguards against pathogens and aberrant cells, with CD4+ T cells playing a central role in this process. Human space travel presents unique health challenges, such as heavy ion ionizing radiation, microgravity, and psychological stress, which can collectively impede immune function. The aim of this research was to examine the consequences of simulated space stressors on CD4+ T cell activation, cytokine production, and gene expression.

Methods

CD4+ T cells were obtained from healthy individuals and subjected to Fe ion particle radiation, Photon irradiation, simulated microgravity, and hydrocortisone, either individually or in different combinations. Cytokine levels for Th1 and Th2 cells were

SUBMITTER: Miranda S 

PROVIDER: S-EPMC11402665 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature