Efficacy and safety of denosumab and teriparatide versus oral bisphosphonates to treat postmenopausal osteoporosis: a systematic review and meta-analysis.

ABSTRACT:

Study design

A systematic review and Meta-analysis.

Objective

To compare the efficacy and safety of denosumab and teriparatide versus oral bisphosphonates to treat postmenopausal osteoporosis.

Summary of background data

While bisphosphonates have historically been the cornerstone of pharmacological management for bone protection in patients, emerging evidence suggests that teriparatide and denosumab warrant further investigation as potential first-line treatments. The optimal choice among denosumab, teriparatide, and oral bisphosphonates for the treatment of postmenopausal osteoporosis remains a subject of ongoing debate and controversy within the scientific community.

Methods

This systematic review adhered meticulously to the rigorous standards outlined by the

SUBMITTER: Yang J 

PROVIDER: S-EPMC11402677 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature