Causal relationship between modifiable risk factors and knee osteoarthritis: a Mendelian randomization study.

ABSTRACT:

Background

While several risk factors for knee osteoarthritis (KOA) have been recognized, the pathogenesis of KOA and the causal relationship between modifiable risk factors and KOA in genetic epidemiology remain unclear. This study aimed to determine the causal relationship between KOA and its risk factors.

Methods

Data were obtained from published Genome-Wide Association study (GWAS) databases. A two-sample Mendelian randomization (MR) analysis was performed with genetic variants associated with risk factors as instrumental variables and KOA as outcome. First, inverse variance weighting was used as the main MR analysis method, and then a series of sensitivity analyses were conducted to comprehensively evaluate the causal relationship between them.

Results

Univariate

SUBMITTER: Diao Z 

PROVIDER: S-EPMC11402680 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature