Causal associations between gut microbiota and premature rupture of membranes: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous study has indicated a potential link between gut microbiota and maternal pregnancy outcomes. However, the causal relationship between gut microbiota and premature rupture of membranes (PROM) remains a topic of ongoing debate.

Methods

A two-sample Mendelian Randomization (MR) study was used to investigate the relationship between gut microbiota and PROM. Genetic data on gut microbiota was obtained from the MiBioGen consortium's largest genome-wide association study (GWAS) (n=14,306). Genetic data on PROM (3011 cases and 104247 controls) were sourced from publicly available GWAS data from the Finnish National Biobank FinnGen consortium. Various methods including Inverse variance weighted (IVW), MR-Egger, simple mode, weighted median, and weighted mode were

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11402717 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature