Paraventricular oxytocin neurons impact energy intake and expenditure: projections to the bed nucleus of the stria terminalis reduce sucrose consumption.

ABSTRACT:

Background

The part played by oxytocin and oxytocin neurons in the regulation of food intake is controversial. There is much pharmacological data to support a role for oxytocin notably in regulating sugar consumption, however, several recent experiments have questioned the importance of oxytocin neurons themselves.

Methods

Here we use a combination of histological and chemogenetic techniques to investigate the selective activation or inhibition of oxytocin neurons in the hypothalamic paraventricular nucleus (Oxt^PVH). We then identify a pathway from Oxt^PVH neurons to the bed nucleus of the stria terminalis using the cell-selective expression of channel rhodopsin.

Results

Oxt^PVH neurons increase their expression of cFos after both physio

SUBMITTER: Worth AA 

PROVIDER: S-EPMC11402739 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature