Chinese acupuncture: A potential treatment for autism rat model via improving synaptic function.

ABSTRACT:

Purpose

Autistic symptom improvement can be observed in children treated with acupuncture, but the mechanism is still being explored. In the present study, we used scalp acupuncture to treat autism rat model, and then their improvement in the abnormal behaviors and specific mechanisms behind were revealed by detecting animal behaviors, analyzing the RNA sequencing of the prefrontal cortex (PFC), and observing the ultrastructure of PFC neurons under the transmission electron microscope.

Methods

On gestational day 12.5, Wistar rats were given valproic acid (VPA) by intraperitoneal injection, and their offspring were considered to be reliable rat models of autism. They were randomized to VPA or VPA-acupuncture group (n = 8). Offspring of Wistar pregnant rats that were simultane

SUBMITTER: Chen S 

PROVIDER: S-EPMC11402746 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature