Causal pathways in preeclampsia: a Mendelian randomization study in European populations.

ABSTRACT:

Purpose

Our study utilizes Mendelian Randomization (MR) to explore the causal relationships between a range of risk factors and preeclampsia, a major contributor to maternal and perinatal morbidity and mortality.

Methods

Employing the Inverse Variance Weighting (IVW) approach, we conducted a comprehensive multi-exposure MR study analyzing genetic variants linked to 25 risk factors including metabolic disorders, circulating lipid levels, immune and inflammatory responses, lifestyle choices, and bone metabolism. We applied rigorous statistical techniques such as sensitivity analyses, Cochran's Q test, MR Egger regression, funnel plots, and leave-one-out sensitivity analysis to address potential biases like pleiotropy and population stratification.

Results

Our analysis i

SUBMITTER: Tan Z 

PROVIDER: S-EPMC11402816 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature