The causal association between gut microbiota and postpartum depression: a two-sample Mendelian randomization study.

ABSTRACT:

Background

An escalating body of clinical trials and observational studies hints at a plausible link between gut flora and postpartum depression (PPD). The definitive causal dynamics between these two entities remain shrouded in ambiguity. Therefore, in this study, we employed the two-sample Mendelian randomization approach to ascertain the causal link between gut microbiota and PPD.

Methods

Summary-level GWAS data related to the human gut microbiota were obtained from the international consortium MiBioGen and the Dutch Microbiome Project (species). For PPD, GWAS data were derived from the FinnGen biobank, consisting 57,604 cases and 596,601 controls. The inverse variance weighted method (IVW) as the cornerstone of our analytical approach. Subsequent to this, a comprehensive

SUBMITTER: Jin W 

PROVIDER: S-EPMC11402819 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature