Locoregional recurrence in studies of primary systemic therapy in early invasive breast cancer.

ABSTRACT:

Introduction

The use of primary systemic therapy (PST) in early invasive breast cancer is routine but there are concerns about risk of locoregional recurrence.

Methods

We conducted a systematic literature review to identify studies of locoregional treatment and recurrence in patients with early invasive breast cancer who received non-endocrine PST.

Results

We identified 112 studies (18 prospective trials and 94 non-interventional studies). The use of surgery and radiotherapy after PST was recorded in 65 (58 %) and 50 (45 %) of studies respectively. 66 (59 %) studies reported locoregional recurrence. Cumulative 5-year locoregional recurrence risks varied from 1 % to 23 %. Locoregional recurrence was higher in patients under the age of 40, those who did not achieve a pa

SUBMITTER: Chen L 

PROVIDER: S-EPMC11402831 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature