Differences in endocrine and reproductive responses to substance exposure across generations: highlighting the importance of complementary findings.

ABSTRACT: This article analyzes the results from 112 Extended One-Generation Reproductive Toxicity studies. The objective was to determine if test animals show consistent endocrine and reproductive effects within the same and across different generations and life stages. The analysis, grounded in a comprehensive Binary Matrix, included 530 observed effects and 193 unique, statistically significant associations. Associations' strength was quantified using Jaccard (J) coefficients to measure effect co-occurrence in the same study. Associated effects co-occur infrequently across the whole dataset (median J = 0.231). However, specific patterns emerged: associations of same effects across generations exhibited a higher strength (median J = 0.400) compared to associations of different effects (median J = 

SUBMITTER: Bichlmaier I 

PROVIDER: S-EPMC11402854 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature