Phenotyping lipid profiles in type 2 diabetes: Risk association and outcomes from the Cardiovascular Health Study.

ABSTRACT:

Aims

To determine whether discrete lipid profiles (refer to as lipid phenotyping) can be used to stratify cardiovascular risk in individuals with type 2 diabetes.

Methods and results

Cardiovascular Health Study participants with diabetes and fasting lipid profiles at baseline (n = 866) were categorized separately by level of LDL cholesterol and HDL-C/Triglyceride (Tg) profiles (low Tg/high HDL-C; high Tg/low HDL-C; high Tg only or low HDL-C only). We performed Cox multivariate regression analysis to assess the risk of CVD mortality, incident myocardial infarction (MI), heart failure (HF), stroke, and composite MACE (MI, HF, stroke, and CVD mortality) associated with each lipid category. We also calculated risk estimates for MACE using lipid measures as continuous vari

SUBMITTER: Bleich D 

PROVIDER: S-EPMC11402907 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature