Brain and Systemic Inflammation in De Novo Parkinson's Disease.

ABSTRACT:

Objective

To assess the presence of brain and systemic inflammation in subjects newly diagnosed with Parkinson's disease (PD).

Background

Evidence for a pathophysiologic role of inflammation in PD is growing. However, several key gaps remain as to the role of inflammation in PD, including the extent of immune activation at early stages, potential effects of PD treatments on inflammation and whether pro-inflammatory signals are associated with clinical features and/or predict more rapid progression.

Methods

We enrolled subjects with de novo PD (n = 58) and age-matched controls (n = 62). Subjects underwent clinical assessments, including the Movement Disorder Society-United Parkinson's Disease rating scale (MDS-UPDRS). Comprehensive cognitive assessment meeting MDS Leve

SUBMITTER: Yacoubian TA 

PROVIDER: S-EPMC11403348 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature