Aspirin in the Form of Microneedle Repairs DNA and Reduces Inflammation in Persistent Skin Damage.

ABSTRACT: Skin damage caused by chemical corrosion is currently one of the common skin diseases and poisoning symptoms, with nitrogen mustard compounds causing the most persistent and severe damage. These chemicals penetrate the top layer of the skin, enter the dermis, and cause DNA damage, oxidative stress, and inflammation. However, to date, no effective drug treatment has been found. Even the potential antidotes could not effectively penetrate the top layer of the skin to exert their effects due to the skin barrier. To address this problem, an innovative transdermal drug delivery strategy based on aspirin microneedles was proposed. The classic medicine aspirin was first discovered not only to reduce inflammation and oxidative stress but also to promote DNA repair and reduce DNA damage. The aspiri

SUBMITTER: Cao W 

PROVIDER: S-EPMC11403356 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature