Traumatic bleeding and mortality in mice are intensified by iron deficiency anemia and can be rescued with tranexamic acid.

ABSTRACT:

Background

Clinical evidence suggests that anemia exacerbates traumatic bleeding and worsens outcomes.

Objectives

To study the influence of iron deficiency anemia on traumatic bleeding, coagulopathy, and mortality.

Methods

C57BL/6J mice received an iron-deficient diet (8 weeks; ±1 mg intraperitoneal iron dextran 2 weeks before trauma). Control mice received a normal diet. Iron deficiency anemia was confirmed by hematocrit, red cell indices, and liver iron. Mice received saline or tranexamic acid (TXA; 10 mg/kg) just before liver laceration. Blood loss, coagulopathy (activated partial thromboplastin time, factor [F]II, FV, FVIII, FX, and fibrinogen), D-dimer, thrombin-antithrombin complexes, and plasmin-alpha-2-antiplasmin complexes were analyzed at 15 and 60 minutes,

SUBMITTER: Joseph BC 

PROVIDER: S-EPMC11403369 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature