Causal relationship between dietary intake and IgA nephropathy: a Mendelian randomization study.

ABSTRACT:

Objective

Previous studies have reported that dietary intake is associated with immunoglobulin A nephropathy (IgAN). However, the causal relationship remains unknown. Based on publicly available genome-wide association study (GWAS) data, we conducted a two-sample Mendelian randomization (MR) analysis to assess the causal association between 26 dietary exposures and IgAN.

Methods

Five methods, including inverse variance weighting (IVW), MR-Egger regression, weighted median, simple mode, and weighted mode, were applied in the MR analysis. To identify the presence of horizontal pleiotropy, we used the MR-Egger intercept test and MR pleiotropy residual sum and outlier (MR-PRESSO) global test. Cochran's Q statistics were used to assess instrument heterogeneity. We conducted sensi

SUBMITTER: Li Y 

PROVIDER: S-EPMC11403370 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature