Suzuki-Miyaura cross-coupling of unprotected ortho-bromoanilines with benzyl, alkyl, aryl, alkenyl and heteroaromatic boronic esters.

ABSTRACT: A Suzuki-Miyaura cross-coupling reaction was developed on unprotected ortho-bromoanilines. This operationally simple reaction was developed for the diversification of glucocorticoid receptor modulators (GRMs), showed compatibility to various boronic esters featuring unique functionalities, and was demonstrated on a gram scale.

SUBMITTER: Lubaev AE 

PROVIDER: S-EPMC11403387 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature