Diphasic CeO₂ Nanocrystal/Bioactive Glass Nanosphere-Based Composite Hydrogel for Diabetic Wound Healing by Reactive Oxygen Species Scavenging and Inflammation Regulation.

ABSTRACT: Background: Antioxidant therapy aimed at reducing excessive local oxidative stress is one of the most important strategies for promoting diabetic wound repair. The reversible transformation of Ce³⁺/Ce⁴⁺ in ceria (CeO₂) can reduce excessive local oxidative stress. However, inducing angiogenesis, local anti-inflammatory effects, and other positive effects are challenging. Therefore, ideal dressings for chronic diabetic wound management must concurrently reduce excessive oxidative stress, promote angiogenesis, and have anti-inflammatory effects. Methods: In this study, Ce-doped borosilicate bioactive glasses (BGs) were prepared using the sol-gel method, and CeO₂ nanocrystals (CeO₂-NCs) were precipitated on the glass surface

SUBMITTER: Qin M 

PROVIDER: S-EPMC11403469 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature