A Bioinspired Nonheme Fe^III-(O₂^2-)-Cu^II Complex with an S_t = 1 Ground State.

ABSTRACT: Cytochrome c oxidase (CcO) is a heme copper oxidase (HCO) that catalyzes the natural reduction of oxygen to water. A profound understanding of some of the elementary steps leading to the intricate 4e^-/4H⁺ reduction of O₂ is presently lacking. A total spin S_t = 1 Fe^III-(O₂^2-)-Cu^II (I_P) intermediate is proposed to reduce the overpotentials associated with the reductive O-O bond rupture by allowing electron transfer from a tyrosine moiety without the necessity of any spin-surface crossing. Direct evidence of the involvement of I_P in the CcO catalytic cycle is, however, missing. A number of heme copper peroxido complexes have been prepared as syntheti

SUBMITTER: Kass D 

PROVIDER: S-EPMC11403606 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature