Arcopilins: A New Family of <i>Staphylococcus aureus</i> Biofilm Disruptors from the Soil Fungus <i>Arcopilus navicularis</i>.

ABSTRACT: Biofilms represent a key challenge in the treatment of microbial infections; for instance, Staphylococcus aureus causes chronic or fatal infections by forming biofilms on medical devices. Herein, the fungus Arcopilus navicularis was found to produce a novel family of PKS-NRPS metabolites that are able to disrupt preformed biofilms of S. aureus. Arcopilins A-F (1-6), tetramic acids, and arcopilin G (7), a 2-pyridone, were elucidated using HR-ESI-MS and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy. Their absolute configuration was established by the synthesis of MPTA-esters for 2, analysis of ¹H-¹H coupling constants, and ROESY correlations, along with comparison with the cry

SUBMITTER: Charria-Giron E 

PROVIDER: S-EPMC11403616 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature