Association between antibiotic usage during infancy and asthma incidence among children: a population-level ecological study in British Columbia, Canada.

ABSTRACT:

Background

This study follows published associations in BC to 2014 (updated in 2019) to model the predicted incidence of asthma in BC children attributable to antibiotic use within the context of reduced antibiotic use and increased breastfeeding in BC infants from 2000 to 2019.

Methods

A population-based ecological study was conducted in BC from 2000 to 2019, using outpatient antibiotic prescription data from BC PharmaNet and asthma diagnoses from the Chronic Disease Registry. Breastfeeding estimates were calculated using the Canadian Community Health Survey (CCHS). Population attributable risk (PAR) was calculated using a blended relative risk (RR) of asthma in antibiotic-exposed children who were and were not breastfed. PAR was used to calculate predicted vs. actual asthm

SUBMITTER: Mamun AA 

PROVIDER: S-EPMC11403638 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature