Evidence of survival bias in the association between APOE-Є4 and age at ischemic stroke onset.

ABSTRACT:

Introduction

Large genome-wide association studies (GWASs) using case-control study designs have now identified tens of loci associated with ischemic stroke (IS). As a complement to these studies, we performed GWAS in a case-only design to identify loci influencing the age at onset (AAO) of ischemic stroke.

Methods

Analyses were conducted in a discovery cohort of 10,857 ischemic stroke cases using a linear regression framework. We meta-analyzed all SNPs with p-value <1 x 10^-5 in a sexcombined or sex-stratified analysis using summary data from two additional replication cohorts.

Results

In the women-only meta-analysis, we detected significant evidence for the association of AAO with rs429358, an exonic variant in apolipoprotein E (APOE) that en

SUBMITTER: von Berg J 

PROVIDER: S-EPMC11403718 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature