Cumulative live birth rate of a blastocyst versus cleavage stage embryo transfer policy during in vitro fertilisation in women with a good prognosis: multicentre randomised controlled trial.

ABSTRACT:

Objectives

To evaluate whether embryo transfers at blastocyst stage improve the cumulative live birth rate after oocyte retrieval, including both fresh and frozen-thawed transfers, and whether the risk of obstetric and perinatal complications is increased compared with cleavage stage embryo transfers during in vitro fertilisation (IVF) treatment.

Design

Multicentre randomised controlled trial.

Setting

21 hospitals and clinics in the Netherlands, 18 August 2018 to 17 December 2021.

Participants

1202 women with at least four embryos available on day 2 after oocyte retrieval were randomly assigned to either blastocyst stage embryo transfer (n=603) or cleavage stage embryo transfer (n=599).

Interventions

In the blastocyst group and cleavage group, embryo tra

SUBMITTER: Cornelisse S 

PROVIDER: S-EPMC11403767 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature