Modelling wound area in studies of wound healing interventions.

ABSTRACT:

Background

Experimental studies of wound healing often use survival analysis and time to event outcomes or differences in wound area at a specific time point. However, these methods do not use a potentially large number of observations made over the course of a trial and may be inefficient. A model-based approach can leverage all trial data, but there is little guidance on appropriate models and functional forms to describe wound healing.

Methods

We derive a general statistical model and review a wide range of plausible mathematical models to describe wound healing. We identify a range of possible derived estimands and their derivation from the models. Using data from a trial of an intervention to promote ulcer healing in patients affected by leprosy that included three meas

SUBMITTER: Watson SI 

PROVIDER: S-EPMC11403831 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature