Integrated analysis of N6-methyladenosine- and 5-methylcytosine-related long non-coding RNAs for predicting prognosis in cervical cancer.

ABSTRACT:

Background

N6-methyladenosine (m⁶A) and 5-methylcytosine (m⁵C) play a role in modifying long non-coding RNAs (lncRNAs) implicated in tumorigenesis and progression. This study was performed to evaluate prognostic value of m⁶A- and m⁵C-related lncRNAs and develop an efficient model for prognosis prediction in cervical cancer (CC).

Methods

Using gene expression data of TCGA set, we identified m⁶A- and m⁵C-related lncRNAs. Consensus Clustering Analysis was performed for samples subtyping based on survival-related lncRNAs, followed by analyzing tumor infiltrating immune cells (TIICs). Optimal signature lncRNAs were obtained using lasso Cox regression analysis for constructing a prognostic model and a nomogram to pr

SUBMITTER: Gao J 

PROVIDER: S-EPMC11403863 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature