Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity.

ABSTRACT: Neurodegenerative disorders comprise a series of heterogeneous conditions that affect millions of people worldwide, representing a significant health burden in both developed and developing countries. Without disease-modifying treatments currently available, the development of effective neurotherapeutics is a health priority. In this work, a new series of peptide-conjugates of the Glypromate neuropeptide is reported to determine the interplay of annular constriction and neuroprotective activity. To this end, (1R,3S,4S)-2-azanorbornane-3-carboxylic acid was used as an l-proline and l-pipecolic acid surrogate in addition to functionalization of the glutamate residue with relevant active pharmaceutical ingredients (APIs), namely amantadine, memantine, and (R)-1-ami

SUBMITTER: Silva-Reis SC 

PROVIDER: S-EPMC11403921 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature