Lipid levels and multiple myeloma risk: insights from Meta-analysis and mendelian randomization.

ABSTRACT:

Background

Lipid levels have been suggset to be correlated with multiple myeloma (MM) risk, though causality remains unconfirmed. To explore this further, a detailed study combining meta-analysis and Mendelian randomization (MR) was conducted.

Methods

Literature searches were performed on PubMed and Embase; summary data for plasma lipid traits were extracted from the IEU and MM data from the FinnGen database. Meta-analysis and MR were utilized to analyze the link of lipids with MM risk, including mediator MR to identify potential mediators. The study was conducted in accordance with PRISMA and STROBE-MR guidelines.

Results

Observational studies analyzed through meta-analysis showed that elevated levels of LDL, HDL, total cholesterol (TC), and triglycerides correlate w

SUBMITTER: Zhu W 

PROVIDER: S-EPMC11404000 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature