Sex-related differences in efficacy of bone marrow-derived high aldehyde dehydrogenase activity cells against pulmonary fibrosis.

ABSTRACT:

Background

Although bone marrow-derived cells with high aldehyde dehydrogenase activity (ALDH^br) have shown therapeutic potential against various diseases in animal studies, clinical trials have failed to show concurrent findings. We aimed to clarify the optimal conditions for the efficacy of ALDH^br cells by using a murine bleomycin-induced pulmonary fibrosis model.

Methods

We intravenously transferred male or female donor C57BL/6 mice-derived ALDH^br cells into recipient C57BL/6 mice under various conditions, and used mCherry-expressing mice as a donor to trace the transferred ALDH^br cells.

Results

Pulmonary fibrosis improved significantly when (1) female-derived, not male-derived, and (2) lineage (Lin)-negative, not lineage

SUBMITTER: Inada S 

PROVIDER: S-EPMC11404015 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature