Effects of silver-decorated PLGA nanoparticles on Staphylococcus epidermidis biofilms and evaluation of the detoxification limit of bacteria against these nanoparticles.

ABSTRACT: Silver nanoparticles exert high antibacterial activity and thus have been used in polymeric formulations for drug delivery. In recent years, polymeric formulations containing silver nanoparticles have been found to be highly effective against biofilm infections, which are difficult to treat with drugs only. However, the antibacterial effects of silver nanoparticles in polymer composites depending on administration time are still unknown. In this study, we used transmission electron microscopy to investigate the antibacterial activity of silver decorated poly(dl-lactide-co-glycolide) (PLGA) (Ag PLGA) nanoparticles against Staphylococcus epidermidis biofilms at different treatment times. LIVE/DEAD assay result showed that approximately 85% of the bacteria in the biofilms was ki

SUBMITTER: Takahashi C 

PROVIDER: S-EPMC11404029 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature