A pre-vaccination immune metabolic interplay determines the protective antibody response to a dengue virus vaccine.

ABSTRACT: Protective immunity to dengue virus (DENV) requires antibody response to all four serotypes. Systems vaccinology identifies a multi-OMICs pre-vaccination signature and mechanisms predictive of broad antibody responses after immunization with a tetravalent live attenuated DENV vaccine candidate (Butantan-DV/TV003). Anti-inflammatory pathways, including TGF-β signaling expressed by CD68^low monocytes, and the metabolites phosphatidylcholine (PC) and phosphatidylethanolamine (PE) positively correlate with broadly neutralizing antibody responses against DENV. In contrast, expression of pro-inflammatory pathways and cytokines (IFN and IL-1) in CD68^hi monocytes and primary and secondary bile acids negatively correlates with broad DENV-specific antibody responses. Induction o

SUBMITTER: Pelletier AN 

PROVIDER: S-EPMC11404042 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature