Investigating immune profile by CyTOF in patients with eosinophilic esophagitis after treatment with orodispersible budesonide.

ABSTRACT: Eosinophilic esophagitis (EoE) is a chronic Th2-mediated inflammatory disease of the esophagus driven by dietary or inhalant allergens which if left untreated, leads to fibrosis and poor esophageal function. Although the inflammation in the esophagus is dominated by eosinophils, there are also elevated levels of T and B cells. Blood samples from ten patients with EoE before and after treatment with orodispersible budesonide and 10 healthy controls were compared using cytometry by time-of-flight. An antibody panel was designed that covers the major immunological cell populations with a particular focus on eosinophils. The data was analyzed with multivariate methods and cluster analysis. Correlation analysis was done between immune markers and endoscopic, histological, and symptomatologic as

SUBMITTER: Plate J 

PROVIDER: S-EPMC11404122 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature