Positional information modulates transient regeneration-activated cell states during vertebrate appendage regeneration.

ABSTRACT: Injury is common in the life of organisms. Because the extent of damage cannot be predicted, injured organisms must determine how much tissue needs to be restored. Although it is known that amputation position affects the regeneration speed of appendages, mechanisms conveying positional information remain unclear. We investigated tissue dynamics in regenerating caudal fins of the African killifish (Nothobranchius furzeri) and found position-specific, differential spatial distribution modulation, persistence, and magnitude of proliferation. Single-cell RNA sequencing revealed a transient regeneration-activated cell state (TRACS) in the basal epidermis that is amplified to match a given amputation position and expresses components and modifiers of the extracellular matrix (ECM). Notab

SUBMITTER: Ortega Granillo A 

PROVIDER: S-EPMC11404194 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature