Convergence of SARS-CoV-2 spike antibody levels to a population immune setpoint.

ABSTRACT:

Background

Individual immune responses to SARS-CoV-2 are well-studied, while the combined effect of these responses on population-level immune dynamics remains poorly understood. Given the key role of population immunity on pathogen transmission, delineation of the factors that drive population immune evolution has critical public health implications.

Methods

We enrolled individuals 5 years and older selected using a multistage cluster survey approach in the Northwest and Southeast of the Dominican Republic. Paired blood samples were collected mid-pandemic (Aug 2021) and late pandemic (Nov 2022). We measured serum pan-immunoglobulin antibodies against the SARS-CoV-2 spike protein. Generalized Additive Models (GAMs) and random forest models were used to analyze the relationsh

SUBMITTER: Nilles EJ 

PROVIDER: S-EPMC11404201 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature