Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation.

ABSTRACT: Restoring somatosensory feedback in individuals with lower-limb amputations would reduce the risk of falls and alleviate phantom limb pain. Here we show, in three individuals with transtibial amputation (one traumatic and two owing to diabetic peripheral neuropathy), that sensations from the missing foot, with control over their location and intensity, can be evoked via lateral lumbosacral spinal cord stimulation with commercially available electrodes and by modulating the intensity of stimulation in real time on the basis of signals from a wireless pressure-sensitive shoe insole. The restored somatosensation via closed-loop stimulation improved balance control (with a 19-point improvement in the composite score of the Sensory Organization Test in one individual) and gait stability (with a

SUBMITTER: Nanivadekar AC 

PROVIDER: S-EPMC11404213 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature