CCL22 as an independent prognostic factor in endometrial cancer patients.

ABSTRACT:

Objectives

The chemokine CCL22 is recognized for recruiting immunosuppressive regulatory T-cells (Treg) that contribute to disease progression in various tumor entities helping them to evade the host immune response. Our study aims to identify the expressing cell types and to evaluate the prognostic significance of CCL22 secretion and its association with Treg invasion in endometrial cancer (EC), an immunogenic cancer.

Methods

Specimens from 275 patients with EC and 28 healthy controls were screened immunohistochemically for CCL22. Immunofluorescence double-staining for CCL22 and different immune cell markers was performed. In vitro regulation of CCL22-expression was examined in EC cell lines (Ishikawa+, RL95-2) and human PBMCs in coculture settings via qPCR and ELISA.

Re

SUBMITTER: Mannewitz M 

PROVIDER: S-EPMC11404215 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature